term.subject="pharmacokinetics"

Summary: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching

Summary: Understanding the science of pharmacokinetics is a challenge for many pharmacy students and practitioners. Concepts in Clinical Pharmacokinetics, now in its 7th edition, has helped thousands by simplifying this essential, but complex, subject to reflect current practice. The 7th edition has been revised by Robin Southwood, PharmD, BC-ADM, CDE; Virginia H. Fleming, PharmD, BCPS; and Gary Huckaby, PharmD; all experts in clinical pharmacy education. Together, they have updated and expanded the text to include the latest information and insights on concepts through extensive use of correlates, figures, and review questions. Inside you will find: * 15 easy-to-follow lessons, perfect for a semester * Practice quizzes to help chart progress * Enhanced discussion of hemodialysis * A phenytoin "cheat sheet" to help you through the calculations maze * New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations * Expanded information on modified diet in renal disease formula versus Cockcroft-Gault formula methods * Factors to consider when choosing a dosing/body weight for various equations * Updated clinical correlates, discussion points, references, and questions/answers Concepts in Clinical Pharmacokinetics is the fundamental reference for learning the basic, foundational pharmacokinetics concepts and how to apply them in clinical practice

Summary: "The new edition of Clinical Manual of Psychopharmacology in the Medically Ill continues the legacy and builds on the success of the first edition by offering a thoroughly up-to-date, comprehensive, and practical guide to the prescription of psychotropic medications in patients with medical illness. The book addresses the prevalence of psychiatric illness in patients with serious medical illness, the complications that may arise, and the implications for psychopharmacological treatment. There is increasing recognition that patients with medical and psychiatric comorbidity have more functional impairment, disability days, emergency department use, rehospitalization, and other medical care costs than do those without such comorbidity. As a result, health care systems have been incentivized to develop new and innovative models of population-based care that integrate medical and psychiatric care in an effort to increase quality and prevention while decreasing use of expensive services such as emergency department visits and hospitalizations. The book is a valuable guide for clinicians across a range of specialties operating in this new, more demanding health care environment. The manual addresses critically important topics through the use of a variety of user-friendly features: " Psychiatric drugs that have become available since the first edition, as well as all recent relevant randomized controlled trials, systematic reviews, and meta-analyses, are covered thoroughly." Each chapter addresses key differential diagnostic considerations and adverse neuropsychiatric side effects of disease-specific medications." Disease-specific pharmacokinetic principles in drug prescribing, including interactions between psychotropic drugs and disease-specific drugs, are also addressed." Key summary points pertaining to psychotropic prescribing in the specific medical disease(s) or specialty area covered are included at the end of each chapter, and a multitude of useful tables summarizing the most important information are provided as well." Chapters are heavily referenced with source information should readers wish to expand their knowledge in a specific area. The chapter authors were selected for their expertise in each area, then the text was edited for consistency, clarity, and maximum utility. Clinical Manual of Psychopharmacology in the Medically Ill is a rigorous and illuminating guide to this vital topic, and clinicians from a variety of specialties will find it indispensable."

Anesthetists can make use of a wide range of drug treatments and this book provides readily available and accessible information on the appropriate drug to use in any given situation

Summary: This book provides a practical introduction to the main concepts of pharmacokinetics and how they can be applied in clinical settings, without using complicated mathematical equations. Essential information on approaches to drug-dosing and monitoring in special populations, including patients with renal and hepatic diseases and elderly patients, are given. Charts, illustrations and examples of calculations are added to clarify concepts and terminology of pharmacokinetics. It's a guide for students and clinicians who want clear, useful guidance to the basic principles of pharmacokinetics and th